B-cell immunity in CNS tumors

Understanding the mechanisms of the tumor microenvironment (TME) induced immunosuppression in glioblastoma is key to developing more potent immunotherapies. This immunosuppression is mediated by cells such as myeloid-derived suppressor cells (MDSCs), regulatory T and B cells, and a myriad of soluble factors that inhibit anti-tumor immune response. Our work focuses on the effects of the TME on B cells , and how targeting these suppressive pathways can allow us to better leverage B cells to target the tumor