• ERK1/2 phosphorylation predicts survival following anti-PD-1 immunotherapy in recurrent glioblastoma, Nature Cancer, 1-15

    Arrieta VA, Chen AX, Kane JR, Kang SJ, Kassab C, Dmello C, Zhao J, Burdett KB, Upadhyayula PS, Lee-Chang C, Shilati J, Jaishankar D, Chen L, Gould A, Zhang D, Yuan J, Zhao W, Ling X, Burks JK, Laffleur B, Amidei C, Bruce JN, Lukas RV, Yamaguchi JT, Cieremans D, Rothschild G, Basu G, McCord M, Brat DJ, Zhang H, Cooper LA, Zhang B, Sims P, Cloughesy TF, Prins R, Canoll P, Stupp R, Heimberger AB, Horbinski C, Iwamoto FM, Rabadan R, Sonabend AM

  • TOP2B Enzymatic Activity on Promoters and Introns Modulates Multiple Oncogenes in Human Gliomas, Clinical Cancer Research 27 (20), 5669-5680

    Gonzalez-Buendia E, Zhao J, Wang L, Mukherjee S, Zhang D, Arrieta VA, Feldstein E, Kane JR, Kang SJ, Lee-Chang C, Mahajan A, Chen L, Realubit R, Karan C, Magnuson L, Horbinski C, Marshall SA, Sarkaria JN, Mohyeldin A, Nakano I, Bansal M, James CD, Brat DJ, Ahmed A, Canoll P, Rabadan R, Shilatifard A, Sonabend AM

  • Neural stem cell delivery of an oncolytic adenovirus in newly diagnosed malignant glioma: A first-in-human, phase 1, dose-escalation trial, The Lancet Oncology 22 (8), 1103-1114

    Fares F, Ahmed AU, Ulasov IV, Sonabend AM, Miska J, Lee-Chang C, Balyasnikova IV, Chandler JP, Portnow J, Tate MC, Kumthekar P, Lukas RV, Grimm SA, Adams AK, Hébert CD, Strong TV, Amidei C, Arrieta VA, Zannikou M, Horbinski C, Zhang H, Burdett KB, Curiel DT, Sachdev S, Aboody KS, Stupp R, Lesniak MS

  • Schlafen 5 as a novel therapeutic target in pancreatic ductal adenocarcinoma, Oncogene, 40 (18), 3273-3286

    Fischietti M, Eckerdt F, Blyth GT, Arslan AD, Mati WM, Oku CV, Perez RE, Lee-Chang C, Kosciuczuk EM, Saleiro D, Beauchamp EM, Lesniak MS, Verzella D, Sun L, Fish EN, Yang GY, Qiang W, Platanias LC

  • Polyamines drive myeloid cell survival by buffering intracellular pH to promote immunosuppression in glioblastoma. Science Advances. 2021 Feb 17;7(8):eabc8929

    Miska J, Rashidi A, Lee-Chang C, Gao P, Lopez-Rosas A, Zhang P, Burga R, Castro B, Xiao T, Han Y, Burns M, Reshetnyak YK, Chandel NS, Lesniak M.

  • Activation of 4-1BBL+ B cells with CD40 agonism and IFNg elicits potent immunity against glioblastoma. J Exp Med. (2021) 218 (1): e20200913 (Corresponding author)

    Lee-Chang C, Miska J, Hou D, Rashidi A, Zhang P, Burga R.A, Jusué-Torres I, Xiao T, Arrieta V.A, Zhang DY, Lopez-Rosas A, Han Y, Sonabend A.M, Horbinski C.M, Stupp R, Balyasnikova I.V, Lesniak M.S,

  • CD8 + T-cell-Mediated Immunoediting Influences Genomic Evolution and Immune Evasion in Murine Gliomas. Clin Cancer Res. 2020 Aug 15;26(16):4390-4401.

    Kane JR, Zhao J, Tsujiuchi T, Laffleur B, Arrieta VA, Mahajan A, Rao G, Mela A, Dmello C, Chen L, Zhang DY, González-Buendia E, Lee-Chang C, Xiao T, Rothschild G, Basu U, Horbinski C, Lesniak MS, Heimberger AB, Rabadan R, Canoll P, Sonabend AM

  • GCN2 is Essential for CD8+ T-cell Survival and Function in Murine Models of Malignant Glioma. Cancer Immunol Immunother. 2020 Jan;69(1):81-94.

    Rashidi A, Miska J, Lee-Chang C, Kanojia D, Panek WK, Lopez-Rosas A, Zhang P, Han Y, Xiao T, Pituch KC, Kim JW, Talebian M, Fares J, Lesniak ML

  • Therapeutic nanoparticle targeting of tumor associated myeloid cells synergizes with radiation therapy for glioblastoma. PNAS. 2019 Nov 19;116(47):23714-23723.

    Zhang P, Miska J, Lee-Chang C, Rashidi A, Panek WK, An S, Zannikou M, Lopez-Rosas A, Han Y, Xiao T, Pituch KC, Kanojia D, Balyasnikova IV, Lesniak MS

  • Myeloid-derived suppressive cells promote B cell-mediated immunosuppression via transfer of PD-L1 in glioblastoma. Cancer Immunol Res. 2019 Sep 17.

    Lee-Chang C, Rashidi A, Miska J, Zhang P, Pituch KC, Hou D, Xiao T, Fischietti M, Kang SJ, Appin CL, Horbinski C, Platanias LC, Lopez-Rosas A, Han Y, Balyasnikova IV, Lesniak MS

  • HIF-1α controls tumor infiltration and immunosuppression of regulatory T-cells in glioblastoma. Cell Reports. 2019 Apr 2;27(1):226-237

    Miska J, Lee-Chang C, Rashidi A, Muroski ME, Chang AL, Lopez-Rosas A, Zhang P, Panek WK, Cordero-Casanovas A, Han Y, Ahmed AA, Chandel NS, Lesniak MS

  • Repolarization of myeloid derived suppressor cells via magnetic nanoparticles to promote radiotherapy for glioma treatment. Nanomedicine. 2019 Feb;16:126-137. doi: 10.1016/j.nano.2018.11.015. Epub 2018 Dec 13.

    Wu C, Muroski ME, Miska J, Lee-Chang C, Shen Y, Rashidi A, Zhang P, Xiao T, Han Y, Lopez-Rosas A, Cheng Y, Lesniak MS

  • Local Application of Autologous Platelet-Rich Fibrin Patch (PRF-P). Suppresses Regulatory T Cell Recruitment in a Murine Glioma Model. Mol Neurobiol. 2018 Nov 20. doi: 10.1007/s12035-018-1430-0.

    Panek WK, Pituch KC, Miska J, Kim JW, Rashidi A, Kanojia D, Lopez-Rosas A, Han Y, Yu D, Lee-Chang C, Kane JR, Zhang P, Cordero A, Lesniak MS

  • Commensal bacteria contribute to insulin resistance in aging by activating innate B1a cells. Sci Transl Med. 2018 Nov 14;10(467).

    Bodogai M, O'Connell J, Kim K, Kim Y, Moritoh K, Chen C, Gusev F, Vaughan K, Shulzhenko N, Mattison JA, Lee-Chang C, Chen W, Carlson O, Becker KG, Gurung M, Morgun A, White J, Meade T, Perdue K, Mack M, Ferrucci L, Trinchieri G, de Cabo R, Rogaev E, Egan J, Wu J, Biragyn A

  • Proinflammatory B-cell profile in the early phases of MS predicts an active disease. Neurol Neuroimmunol Neuroinflamm. 2017 Dec 22;5(2):e431

    Guerrier T, Labalette M, Launay D, Lee-Chang C, Outteryck O, Lefèvre G, Vermersch P, Dubucquoi S, Zéphir H

  • Aging impairs innate B1a cells employing dysregulated myeloid cells. Journal of Immunology. 2016 Apr 15;196(8):3385-97.

    Lee-Chang C, Bodogai M, Moritoh K, Chen X, Wersto R, Sen R, Oppenheim J, Young H, Croft M, Ferrucci L, and Biragyn A

  • High-affinity σ1 protein agonist reduces clinical and pathological signs of experimental autoimmune encephalomyelitis. Br J Pharmacol. 2015 Apr;172(7):1769-82.

    Oxombre B, Lee-Chang C, Duhamel A, Toussaint M, Giroux M, Donnier-Maréchal M, Carato P, Lefranc D, Zéphir H, Prin L, Melnyk P, Vermersch P

  • Immune suppressive and pro-metastatic functions of myeloid-derived suppressive cells rely upon education from tumor-associated B cells. Cancer Research. 2015 Sep 1;75(17):3456-65.

    Bodogai M, Moritoh K, Lee-Chang C, Hollander CM, Sherman-Baust CA, Wersto RP, Araki Y, Miyoshi I, Yang L, Trinchieri G and Biragyn A

  • Accumulation of 4-1BBL+ B cells in the elderly induces the generation of granzyme-B+ CD8+ T cells with potential antitumor activity. Blood. 2014 Aug 28;124(9):1450-9.

    Lee-Chang C, Bodogai M, Moritoh K, Olkhanud PB, Chan AC, Croft M, Mattison JA, Holst PJ, Gress RE, Ferrucci L, Hakim F and Biragyn A

  • Inhibition of breast cancer metastasis by resveratrol-mediated inactivation of tumor-evoked regulatory B cells. Journal of Immunology. 2013 Oct 15;191(8):4141-51

    Lee-Chang C, Bodogai M, Martin-Montalvo A, Wejksza K, Sanghvi M, Moaddel R, de Cabo R and Biragyn A

  • Inhibition of lung metastasis by chemokine CCL17-mediated in vivo silencing of genes in CCR4+ Tregs. Journal of Immunotherapy. 2013 May;36(4):258-67

    Biragyn A, Bodogai M, Olkhanud PB, Denny-Brown SR, Puri N, Ayukawa K, Kanegasaki S, Hogaboam CM, Wejksza K and Lee-Chang C

  • Anti-CD20 antibody promotes cancer escape via enrichment of tumor-evoked regulatory B cells expressing low levels of CD20 and CD137L. Cancer Research. 2013 Apr 1;73(7):2127-38

    Bodogai M, Lee-Chang C, Wejksza K, Lai J, Merino M, Wersto RP, Gress RE, Chan AC, Hesdorffer C and Biragyn A

  • Cancer-produced metabolites of 5-lipoxygenase induce tumor-evoked Bregs via peroxisome proliferator-activated receptor alpha. Journal of Immunology. 2013 Mar 15;190(6):2575-84. (*Co-first author)

    Wejksza K*, Lee-Chang C*, Bodogai M, Bonzo J, Gonzalez FJ, Lehrmann E, Becker K, Biragyn A

  • Susceptibility to experimental autoimmune encephalomyelitis is associated with altered B-cell subsets distribution and decreased serum BAFF levels. Immunology Letters. 2011. 135 (1-2):108-17

    Lee-Chang C, Lefranc D, Salleron J, Faveeuw C, Allet C, Vermersch P, Oxombre B, Prin L

  • B-cell subsets up-regulate a4 integrin and accumulate in the cerebrospinal fluid in clinically isolated syndrome suggestive of multiple sclerosis onset. Neuroscience Letters. 2011. 487 (3):273-7

    Lee-Chang C, Zéphir H, Top I, Dubucquoi S, Trauet J, Prin L, Vermersch P

  • Primed status of transitional B cells associated with their presence in the cerebrospinal fluid in early phases of multiple sclerosis. Clinical Immunology. 2011. 139 (1):12-20

    Lee-Chang C, Top I, Zéphir H, Dubucquoi S, Trauet J, Dussart P, Prin L, Vermersch P